For me, I have two main conventions. One for switching to another application and one for capturing information into an app or clipboard.
Control + Option + Command + LETTER to switch applications. So the base modifier stays the same but the letter changes. So
Control + Option + Command + S switches me to Safari.
Control + Option + Command + T switches me to Sublime Text. And on and on it goes. I think I have about 12 of these.
For capturing data, I like to use
Command + Shift + LETTER. So in this case,
Control + Shift + O sends the thing to OmniFocus.
Command + Shift + C copies the thing to the clipboard.
I can’t say for certain how I landed on those but they’re pure muscle memory at this point.
@Tyler_Weitzman, what shortcuts are you trying to set up? Or are you trying to nail down a convention to make it easier to remember?